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专利名称：Block copolymer, micelle preparation, and
anticancer agent containing the same asactive ingredient
发明人：Kazuhisa Shimizu,Keizou Ishikawa,Takeshi
Nakanishi
申请号：US13971036申请日：20130820公开号：US09434822B2公开日：20160906
摘要：A medicinal preparation is desired which has no harmful side effects such ashypersensitive reaction, heightens the water solubility of a sparingly water-solubleanticancer agent, maintains a high drug concentration in the blood, accumulates a drug ina tumor tissue at a high concentration, heightens the pharmacological effect of thesparingly water-soluble anticancer agent, and diminishes the side effects of theanticancer agent. Provided are: a novel block copolymer which can be a drug carrierhaving no harmful side effects such as hypersensitive reaction; a micelle preparation inwhich micelles are formed and which contains a sparingly water-soluble anticancer agent,especially paclitaxel, incorporated in the micelles in an amount necessary for a diseasetreatment without bonding it to the block copolymer and which can heighten thesolubility of the drug in water; and an anticancer agent which comprises the micellepreparation as a medical ingredient, maintains a high concentration in the blood, hasmore potent drug activity, and is reduced in toxicity.
申请人：Nippon Kayaku Kabushiki Kaisha
地址：Chiyoda-ku, Tokyo JP
国籍：JP
代理机构：Nields, Lemack & Frame, LLC
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